Editors' ChoiceNeurobiology

G proteins and Presynaptic Inhibition

STKE  17 Apr 2001:
Vol. 2001, Issue 78, pp. tw5
DOI: 10.1126/stke.2001.78.tw5

Several neurotransmitters modulate synaptic release from presynaptic terminals by activating G-protein-coupled receptors. Blackmer et al. investigated the basic mechanisms underlying this modulation of the exocytotic machinery in neurons. Microinjection of G-protein ßγ-subunits (Gßγ) into lamprey reticulospinal axons inhibited synaptic transmission without decreasing the action potential-dependent influx of Ca2+. This result suggests a potentially new effector role for Gßγ through directly modulating the vesicle fusion machinery in the synaptic terminal.

T. Blackmer, E. C. Larsen, M. Takahashi, T. F. J. Martin, S. Alford, H. E. Hamm, G protein ßγ subunit-mediated presynaptic inhibition: Regulation of exocytotic fusion downstream of Ca2+ entry. Science 292, 293-297 (2001). [Abstract] [Full Text]