Editors' ChoiceDevelopmental Biology

Sharing the Roundabout

Science's STKE  24 Apr 2001:
Vol. 2001, Issue 79, pp. tw9
DOI: 10.1126/stke.2001.79.tw9

The midline of the fruit fly and the zebrafish share more than just topology. Fricke et al. show that zebrafish use a receptor encoded by the gene astray for guiding axons from the developing eyes to the brain, crossing the midline on their way to form the optic chiasma. The astray receptor is similar to the receptor encoded by the gene roundabout that is responsible for guidance of growing axons across the midline in Drosophila. Chimeras made by exchanging eyes of mutant and wild-type zebrafish demonstrated that the relevant site of expression of astray is in the eye.

C. Fricke, J.-S. Lee, S. Geiger-Rudolph, F. Bonhoeffer, C.-B. Chien, astray, a Zebrafish roundabout homolog required for retinal axon guidance. Science 292, 507-510 (2001). [Abstract] [Full Text]