Developmental Biology

Muscle Cells on the Move

Science's STKE  01 May 2001:
Vol. 2001, Issue 80, pp. tw5
DOI: 10.1126/stke.2001.80.tw5

The ligand Slit and its corresponding receptor Roundabout (Robo) are notorious for providing guidance signals to axons finding their initial pathways during early Drosophila development. Kramer et al. now show that the Slit and Robo combination is even more versatile than previously thought. Muscle cells also migrate during the early stages of muscle organization under the direction of the Slit and Robo team. The response switches from repulsive to attractive; initially repelled by Slit at the midline, muscle cells are later attracted by Slit at specific attachment sites.

S. G. Kramer, T. Kidd, J. H. Simpson, C. S. Goodman, Switching repulsion to attraction: Changing responses to Slit during transition in mesoderm migration. Science 292, 737-740 (2001). [Abstract] [Full Text]