New Functions for DNA Binding Domains

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Science's STKE  08 May 2001:
Vol. 2001, Issue 81, pp. pe1
DOI: 10.1126/stke.2001.81.pe1

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How the same transcription factor can be both an activator and a repressor of transcription is a biological mystery. Rao describes work that shows that the structure of the transcription factor may actually change depending on the DNA sequence bound by the factor. This change in structure may influence the binding of activators or repressors of transcription, thus allowing a single transcription factor to have two different activities.

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