Perspective

CREB Signaling-Timing Is Everything

Science's STKE  15 May 2001:
Vol. 2001, Issue 82, pp. pe1
DOI: 10.1126/stke.2001.82.pe1

You are currently viewing the abstract.

View Full Text

Abstract

Depolarization of neurons can lead to changes in gene expression that are important for such processes as synaptic plasticity, neuronal differentiation, and apoptosis. Impey and Goodman discuss some of the opposing models for how gene transcription in response to neuronal activity and elevations in intracellular calcium concentration is regulated. The pathways appear to converge on cyclic AMP response element-binding (CREB) protein, with the mitogen-activated protein kinase pathways playing an important role. The continuing debate about the involvement of calmodulin kinase IV is also described.

View Full Text