Plant biology

Protease in Plant Signaling Pathway

Science's STKE  15 May 2001:
Vol. 2001, Issue 82, pp. tw10
DOI: 10.1126/stke.2001.82.tw10

A plant cell-surface receptor called BRI1 is thought to transduce signals initiated by brassinosteroids (BRs) that regulate growth and development. Genetic analysis of Arabidopsis thaliana mutants by Li et al. has revealed the involvement of a serine carboxypeptidase called BRS1 in this signaling cascade. Overexpression of BRS1 in wild-type plants did not alter growth, but did suppress the effects of BRI1 mutants with defects in their extracellular domain. BRS1 was not able to suppress a cytoplasmic kinase domain mutant of BRI1, nor was it able to act in the absence of BR. The substrates of BRS1 are not yet known, but the enzyme could cleave BRI1 or BR-binding proteins.

J. Li, K. A. Lease, F. E. Tax, J. C. Walker, BRS1, a serine carboxypeptidase, regulates BRI1 signaling in Arabidopsis thaliana. Proc. Natl. Acad. Sci. U.S.A. 10, 5916-5921 (2001). [Abstract] [Full Text]