Editors' ChoiceDevelopmental Biology

Synergy Between Selector and Signaling Proteins

Science's STKE  15 May 2001:
Vol. 2001, Issue 82, pp. tw6
DOI: 10.1126/stke.2001.82.tw6

Throughout development, complex structures such as organs and appendages form as directed by spatial and temporal cues. Studies have begun to define these cues, but we currently do not know how the various cues are integrated. Using the Drosophila wing imaginal disk, Guss et al. (see the Perspective by Affolter and Mann) examined the relation between the selector proteins and signaling factors that influence wing-specific genes. Wing development requires DNA binding by both selector proteins and signaling proteins for the specification of a developmental field.

K. A. Guss, C. E. Nelson, A. Hudson, M. E. Kraus, S. B. Carroll, Control of a genetic regulatory network by a selector gene. Science 292, 1164-1167 (2001). [Abstract] [Full Text]

M. Affolter, R. Mann, Legs, eyes, or wings--Selectors and signals make the difference. Science 292, 1080-1081 (2001). [Abstract] [Full Text]