Cancer Biology

Insights into Cancer

Science's STKE  22 May 2001:
Vol. 2001, Issue 83, pp. tw2
DOI: 10.1126/stke.2001.83.tw2

Understanding the extracellular and intracellular signals that control normal cell growth and proliferation has been central to deciphering the underlying causes of human cancers. Although cells strive to coordinate and balance a plethora of signaling cascades, the slightest perturbation can result in deregulation of critical cellular processes. A collection of articles in Nature that highlight recent progress in the control of the cell division cycle and apoptosis, protein kinase activation, and cell proliferation during embryonic development attests to how future development of effective therapeutics requires an integrated understanding of how deregulation of cell proliferation leads to tumorigenesis.

G. I. Evan, K. H. Vousden, Proliferation, cell cycle and apoptosis in cancer, Nature 411, 342-348 (2001). [Online Journal]

J. Taipale, P. A. Beachy, The hedgehog and Wnt signalling pathways in cancer, Nature 411, 349-354 (2001). [Online Journal]

P. Blume-Jensen, T. Hunter, Oncogenic kinase signalling, Nature 411, 355-365 (2001). [Online Journal]