Perspective

TGF-β Flips the Myc Switch

STKE  26 Jun 2001:
Vol. 2001, Issue 88, pp. pe1
DOI: 10.1126/stke.2001.88.pe1

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Abstract

Although transforming growth factor-β (TGF-β) can affect cell cycle arrest, not much molecular detail is known about how TGF-β-dependent arrest is mediated. Two recent papers shed some light on how this is accomplished. Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15INK4b, and how TGF-β is able to unblock Myc-dependent repression of Miz-1.

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