Transcription activators can recruit the histone acetyltransferase (HAT) complexes SAGA and NuA4 to stimulate transcription from chromatin-assembled DNA templates, but the mechanism for targeting these complexes to promoters is unclear. Brown et al. now demonstrate that acidic activators interact with Tra1p, a subunit that is found in both of these complexes; hence, Tra1p is likely to be an essential component involved in the recruitment of HAT to promoters for the modification of histones.
C. E. Brown, L. Howe, K. Sousa, S. C. Alley, M. J. Carrozza, S. Tan, J. L. Workman, Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292, 2333-2337 (2001). [Abstract] [Full Text]