Restoring LTP

Science's STKE  03 Jul 2001:
Vol. 2001, Issue 89, pp. tw7
DOI: 10.1126/stke.2001.89.tw7

Studies with knockout mice lacking an AMPA receptor subunit (glutamate receptor A, or GluR-A) indicate that after the induction of long-term potentiation (LTP), increased transmission at hippocampal synapses is established and maintained by an increased response of AMPA receptors. In this preparation, the lack of AMPA receptors at nonsynaptic sites has been linked to the absence of LTP. Mack et al. used a conditional knockout preparation of AMPA receptors tagged with green fluorescent protein to show that the GluR-A subunit is essential for pairing-induced LTP at mature hippocampal synapses.

V. Mack, N. Burnashev, K. M. M. Kaiser, A. Rozov, V. Jensen, Ø. Hvalby, P. H. Seeburg, B. Sakmann, R. Sprengel, Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice. Science 292, 2501-2504 (2001). [Abstract] [Full Text]