Destined for Destruction

Sci. STKE, 31 July 2001
Vol. 2001, Issue 93, p. tw2
DOI: 10.1126/stke.2001.93.tw2

Destined for Destruction

When cells are starved, they tend to cannibalize excess proteins. Kuroda et al. (see the Perspective by Gottesman and Maurizi) examined this process in bacteria and discovered that inorganic polyphosphate appears to be a key factor in promoting the specific degradation of unassembled (excess) ribosomal subunits, presumably in order to recycle their constituent amino acids. They propose that the inorganic polyphosphate binds noncovalently to the ribosomal proteins and targets them for degradation by the adenosine triphosphate-dependent protease, Lon.

A. Kuroda, K. Nomura, R. Ohtomo, J. Kato, T. Ikeda, N. Takiguchi, H. Ohtake, A. Kornberg, Role of inorganic polyphosphate in promoting ribosomal protein degradation by the Lon protease in E. coli. Science 293, 705-708 (2001). [Abstract] [Full Text]

S. Gottesman, M. R. Maurizi, Surviving starvation. Science 293, 614-615 (2001). [Full Text]


Destined for Destruction. Sci. STKE 2001, tw2 (2001).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882