Perspective

Neuronal Signaling through Alternative Splicing: Some Exons CaRRE...

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Science's STKE  07 Aug 2001:
Vol. 2001, Issue 94, pp. pe2
DOI: 10.1126/stke.2001.94.pe2

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Abstract

Alternative splicing represents a mechanism by which a single gene can be used to create proteins with different functions. Neurons use alternative splicing to produce channels with different sequences and biophysical or regulatory properties. O'Donovan and Darnell discuss a mechanism by which neurons can alter channel splicing in response to neuronal activity through a signal generated by calcium and calcium/calmodulin-dependent kinase activity.

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