Editors' ChoiceIntracellular Movement

Myosin-V Regulation

Science's STKE  21 Aug 2001:
Vol. 2001, Issue 96, pp. tw8
DOI: 10.1126/stke.2001.96.tw8

Myosin-V is a microtubule-based motor responsible for promoting organelle movements around the cell, particularly the movement of melanophores around melanocytes. During mitosis, the activity of myosin-V is decreased, probably by phosphorylation, as the microtubule machinery is co-opted into spindle assembly and membrane traffic shuts down. Karcher et al. (see the Perspective by Cheney and Rodriguez) describe the precise phosphorylation site that is present in the organelle-binding carboxyl terminal of the protein. The authors suggest that such phosphorylation to abrogate cargo binding may be used more generally.

R. L. Karcher, J. T. Roland, F. Zappacosta, M. J. Huddleston, R. S. Annan, S. A. Carr, V. I. Gelfand, Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. Science 293, 1317-1320 (2001). [Abstract] [Full Text]

R. E. Cheney, O. C. Rodriguez, A switch to release the motor. Science 293, 1263-1264 (2001). [Full Text]