Structural Biology

Maintaining Fluid Homeostasis

Science's STKE  04 Sep 2001:
Vol. 2001, Issue 98, pp. tw12
DOI: 10.1126/stke.2001.98.tw12

Natriuretic peptides are hormones that are involved in the regulation of fluid balance, with particular relevance for cardiovascular function and blood pressure. This family of peptides is recognized by a family of cell surface receptors (NPR-A, -B, and -C). He et al. have determined the crystal structures of the extracellular portion of NPR-C with and without natriuretic peptide C bound. One molecule of the peptide binds to a receptor dimer; binding appears to close the cleft between the monomers.

X. He, D. Chow, M. M. Martick, K. C. Garcia, Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone. Science 293, 1657-1662 (2001). [Abstract] [Full Text]