Editors' ChoiceAngiogenesis

More Strict than VEGF

Science's STKE  04 Sep 2001:
Vol. 2001, Issue 98, pp. tw2
DOI: 10.1126/stke.2001.98.tw2

In a screen for putative human secreted mitogenic factors, Le Couter et al. have found a new molecule that acts like the well-characterized proangiogenic factor vascular endothelial growth factor (VEGF), but is much more selective in its target cells. Endocrine gland-derived VEGF (EG-VEGF) induced proliferation and a chemotactic response from endocrine-derived endothelial cells only, and its expression was also limited to endocrine tissues. However, like that of VEGF, expression of EG-VEGF was induced by hypoxia, and both factors promoted the formation of fenestrated membranes in cultured adrenal cortex-derived capillary endothelial cells. Expression of EG-VEGF in various tissues of rats or mice demonstrated that endocrine tissues were specifically responsive. Hence, EG-VEGF may represent a new type of highly specific mitogen whose selective behavior could be of therapeutic significance.

J. LeCouter, J. Kowalski, J. Foster, P. Hass, Z. Zhang, L. Dillard-Telm, G. Frantz, L. Rangell, L. DeGuzman. G.-A. Keller, F. Peale, A. Gurney, K.J. Hillam, N. Ferrara, Identification of an angiogneic mitogen selective for endocrine gland endothelium. Nature 412: 877-884 (2001). [Online Journal]