Editors' ChoiceNeurobiology

Molecular Basis of Mossy Fiber LTP

STKE  08 Jan 2002:
Vol. 2002, Issue 114, pp. tw13
DOI: 10.1126/stke.2002.114.tw13

Long-term potentiation (LTP) at hippocampal mossy fiber synapses is distinct from most other forms of LTP. Mellor et al. found that the hyperpolarization-activated mixed cation current Ih unexpectedly plays an important role. Calcium entry into the hippocampal granule cells during repetitive stimulation activates a calcium-calmodulin-sensitive adenylate cyclase. The subsequent rise in adenosine 3′,5′-monophosphate (cAMP) activates protein kinase A, which leads to increases in Ih. The resulting depolarization causes an enhancement of mossy fiber synaptic transmission.

J. Mellor, R. A. Nicoll, D. Schmitz, Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels. Science 295, 143-147 (2002). [Abstract] [Full Text]