Editors' ChoiceNeurobiology

Trauma, Stress, and Consequences

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Science's STKE  22 Jan 2002:
Vol. 2002, Issue 116, pp. tw33
DOI: 10.1126/stke.2002.116.tw33

Traumatic stress often causes long-term pathological changes. To elucidate the molecular basis of these stress-induced changes, Meshorer et al. analyzed the regulation of expression of acetylcholinesterase (AChE) splice variants at cholinergic synapses in the central nervous system. They saw a change from the dominant membrane-bound AChE-S form to the rare soluble AChE-R form. This switch could be triggered by various stresses, occurred very rapidly, and could last for many weeks.

E. Meshorer, C. Erb, R. Gazit, L. Pavlovsky, D. Kaufer, A. Friedman, D. Glick, N. Ben-Arie, H. Soreq, Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity. Science 295, 508-512 (2002). [Abstract] [Full Text]