ECM Remodeling Regulates Angiogenesis: Endothelial Integrins Look for New Ligands

Science's STKE  12 Feb 2002:
Vol. 2002, Issue 119, pp. pe7
DOI: 10.1126/stke.2002.119.pe7

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The process of angiogenesis is a dynamic one. Vascular endothelial cells are changing at the same time the extracellular matrix is being remodeled. Stupack and Cheresh discuss how remodeling of the extracellular matrix (ECM) and changes in the endothelial cell protein production and integrin expression contribute to the complex process of new blood vessel growth from an existing vascular bed.

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