Protein Modification

Doing Double Duty

Science's STKE  19 Feb 2002:
Vol. 2002, Issue 120, pp. tw78
DOI: 10.1126/stke.2002.120.tw78

Regulation of the cell cycle involves the nedd8 ubiquitin-like modification of key proteins. Kurz et al. now find that these modifications are also important in controlling the cytoskeleton in Caenorhabditis elegans embryos. Nedd 8 conjugation inhibits microfilament contraction in the cell cortex during pronuclear migration and again during cytokinesis. In addition, katanin, a microtubule-severing complex, is degraded after neddylation at the end of meiosis.

T. Kurz, L. Pintard, J. H. Wills, D. R. Hamill, P. Gönczy, M. Peter, B. Bowerman, Cytoskeletal regulation by the nedd8 ubiquitin-like protein modification pathway. Science 295, 1294-1298 (2002). [Abstract] [Full Text]