Gene Regulation

ACE is the Place

Science's STKE  26 Feb 2002:
Vol. 2002, Issue 121, pp. tw88
DOI: 10.1126/stke.2002.121.tw88

Expression of the ACO gene encoding plant acyl-CoA oxidase is increased in response to ultraviolet (UV) light and decreased in response to pathogen attack or exposure of the plants to elicitors (pathogen-derived signal molecules). Logemann and Hahlbrock found that the same response elements [two AGCT-containing elements (ACE)] in the ACO promoter were responsible for both the UV-stimulated increase in expression of a reporter gene and a decrease in expression upon subsequent exposure to elicitor. Common plant regulatory factors (CPRFs) are transcription factors that interact with ACEs. UV light stimulated CPRF1 transcription, whereas elicitor treatment stimulated CPRF2 transcription and repressed CPRF1 transcription. The results suggest that the same cis-acting sequences allow activation or repression and that a subsequent stress (pathogen) can convert an active promoter into a repressed promoter through interactions at the same cis element, possibly by stimulating a change in the transcription factor bound to the response element.

E. Logemann, K. Hahlbrock, Crosstalk among stress responses in plants: Pathogen defense overrides UV protextion through an inversely regulated ACE/ACE type o flight-responsive gene promoter unit. Proc. Natl. Acad. Sci. U.S.A. 99, 2428-2432 (2002). [Abstract] [Full Text]