Perspective

Molecular BKology: The Study of Splicing and Dicing

Science's STKE  12 Mar 2002:
Vol. 2002, Issue 123, pp. pe12
DOI: 10.1126/stke.2002.123.pe12

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Abstract

The activity of ion channels is regulated by several different mechanisms. Studies have been undertaken to determine how the large-conductance Ca2+-sensitive K+ channel (the BK channel) is regulated. Fury et al. discuss how the presence or absence of alternatively spliced regions in the BK channel α subunit can act as a molecular switch by which different kinases activate the BK channel.

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