ADAP-ting TCR Signaling to Integrins

Sci. STKE, 9 April 2002
Vol. 2002, Issue 127, p. re3
DOI: 10.1126/stke.2002.127.re3

ADAP-ting TCR Signaling to Integrins

  1. Emily K. Griffiths1,2 and
  2. Josef M. Penninger1,2,*
  1. 1Amgen, Departments of Medical Biophysics and Immunology, University of Toronto, 620 University Avenue, Toronto, Ontario, Canada M5G 2C1.
  2. 2Institute for Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr Gasse 7, A-1030 Vienna, Austria.
  1. *Corresponding author. Telephone, 416-204-2244; fax, 416-204-2278; e-mail, jpenning{at}


Adaptor proteins, which contain multiple intermolecular interaction domains, are critical intermediates in T cell receptor (TCR) signaling cascades leading to transcriptional and cytoskeletal changes. Recently, the adaptor adhesion- and degranulation-promoting adaptor protein (ADAP), also known as Fyn binding protein (FYB) or Slp-76-associated protein of 130 kilodaltons (SLAP-130), was demonstrated by genetic methods to couple TCR stimulation to integrin clustering and T cell adhesion.


E. K. Griffiths and J. M. Penninger, ADAP-ting TCR Signaling to Integrins. Sci. STKE 2002, re3 (2002).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882