ADAP-ting TCR Signaling to Integrins

See allHide authors and affiliations

Science's STKE  09 Apr 2002:
Vol. 2002, Issue 127, pp. re3
DOI: 10.1126/stke.2002.127.re3

You are currently viewing the gloss.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


Adaptor proteins, which contain multiple intermolecular interaction domains, are critical intermediates in T cell receptor (TCR) signaling cascades leading to transcriptional and cytoskeletal changes. Recently, the adaptor adhesion- and degranulation-promoting adaptor protein (ADAP), also known as Fyn binding protein (FYB) or Slp-76-associated protein of 130 kilodaltons (SLAP-130), was demonstrated by genetic methods to couple TCR stimulation to integrin clustering and T cell adhesion.