Review

ADAP-ting TCR Signaling to Integrins

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Science's STKE  09 Apr 2002:
Vol. 2002, Issue 127, pp. re3
DOI: 10.1126/stke.2002.127.re3

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Gloss

Adaptor proteins, which contain multiple intermolecular interaction domains, are critical intermediates in T cell receptor (TCR) signaling cascades leading to transcriptional and cytoskeletal changes. Recently, the adaptor adhesion- and degranulation-promoting adaptor protein (ADAP), also known as Fyn binding protein (FYB) or Slp-76-associated protein of 130 kilodaltons (SLAP-130), was demonstrated by genetic methods to couple TCR stimulation to integrin clustering and T cell adhesion.