Controlling the Immune System Through Semaphorins

Sci. STKE, 16 April 2002
Vol. 2002, Issue 128, p. re4
DOI: 10.1126/stke.1282002re4

Controlling the Immune System Through Semaphorins

  1. Georges Bismuth1,* and
  2. Laurence Boumsell2
  1. 1Institut Cochin, Département de Biologie Cellulaire, 22 rue Méchain, 75014 Paris, France.
  2. 2INSERM U448, Faculté de Médecine de Créteil, 8 rue du Général Sarrail, 94010 Créteil, France.
  1. *Corresponding author. E-mail: bismuth{at}


The expression of vertebrate semaphorins was thought to be restricted to the nervous system, where they function as specific guidance cues for neurons. However, semaphorins are also present and function in lymphocytes, opening an unexpected and exciting field of investigations that suggest, in keeping with the concept of the immunological synapse, that immune and neuronal cells may sense their surrounding environments in a similar way.


G. Bismuth and L. Boumsell, Controlling the Immune System Through Semaphorins. Sci. STKE 2002, re4 (2002).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882