Controlling the Immune System Through Semaphorins

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Science's STKE  16 Apr 2002:
Vol. 2002, Issue 128, pp. re4
DOI: 10.1126/stke.1282002re4

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The expression of vertebrate semaphorins was thought to be restricted to the nervous system, where they function as specific guidance cues for neurons. However, semaphorins are also present and function in lymphocytes, opening an unexpected and exciting field of investigations that suggest, in keeping with the concept of the immunological synapse, that immune and neuronal cells may sense their surrounding environments in a similar way.