Physiology

Powering Up Muscle

Science's STKE  16 Apr 2002:
Vol. 2002, Issue 128, pp. tw142
DOI: 10.1126/stke.2002.128.tw142

Abstract

Endurance training enhances the oxidative capacity of skeletal muscle by stimulating the production of mitochondria, the organelles that supply fuel to cells. The molecular signals that mediate this adaptive process are not well understood. Through a study of transgenic mice that express a hyperactive form of calcium, calmodulin-dependent protein kinase IV (CaMKIV) in their skeletal muscle, Wu et al. establish that calcium-regulated signaling pathways play a key in controlling mitochondrial biogenesis in muscle.

H, Wu, S. B. Kanatous, F. A. Thurmond, T. Gallardo, E. Isotani, R. Bassel-Duby, R. S. Williams, Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296, 349-352 (2002). [Abstract] [Full Text]