Damage Control

Science's STKE  23 Apr 2002:
Vol. 2002, Issue 129, pp. tw151
DOI: 10.1126/stke.2002.129.tw151

In the nematode Caenorhabditis elegans, activation of a member of the so-called "forkhead" family of transcription factors can cause an increase in life-span of the organism, perhaps by promoting resistance to oxidative damage or other forms of stress. Tran et al. examined the role of mammalian forkhead family member FOXO3a in stress responses and found that activation of the transcription factor caused a delay in the cell cycle and promoted repair of damaged DNA. Analysis of the transcriptional profile of cells expressing activated FOXO3a revealed a group of genes implicated in cellular stress responses and DNA repair. The results indicate that forkhead transcription factors are key regulators of stress responses in mammals, as well as in worms, and could conceivably influence organismal life-span in this manner.

H. Tran, A. Brunet, J. M. Grenier, S. R. Datta, A. J. Fornace Jr., P. S. DiStefano, L. W. Chiang, M. E. Greenberg, DNA repair pathway stimulated by the Forkhead transcription factor FOXO3a through the Gadd45 protein. Science 296, 530-534 (2002). [Abstract] [Full Text]