Do Defects in Ion Channel Glycosylation Set the Stage for Lethal Cardiac Arrhythmias?

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Science's STKE  30 Apr 2002:
Vol. 2002, Issue 130, pp. pe19
DOI: 10.1126/stke.2002.130.pe19

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Many ion channels are modified by the addition of carbohydrate residues. Fozzard and Kyle discuss evidence that sialic acid residues on glycosylated cardiac sodium and potassim channels may be important for preventing early after-depolarizations that can result in cardiac arrhythmias.

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