Cell Cycle

Cellular Stage Directions

Science's STKE  14 May 2002:
Vol. 2002, Issue 132, pp. tw175
DOI: 10.1126/stke.2002.132.tw175

As the cell progresses through the cell cycle, mechanisms must be present to allow the cell to exit one stage and progess to the next one. Ogawa et al. (see the Perspective by La Thangue) investigate the mechanism by which genes are turned off in the G0 stage by the repressor protein E2F-6. They found that E2F-6 exists in a large complex with other proteins, including several DNA-binding factors, a histone methyltransferase, the transcription repressor HP1, and Polycomb proteins. This multiprotein complex is targeted to E2F-6-responsive promoters in quiescent cells but not G1 cells. As malignant tumor cells have lost the ability to enter the G0 stage, the elucidation of the mechanisms governing cell-cycle-dependent gene expression may reveal important information about cell regulation.

H. Ogawa, K. Ishiguro, S. Gaubatz, D. M. Livingston, Y. Nakatani, A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science 296, 1132-1136 (2002). [Abstract] [Full Text]

N. B. La Thangue, Chromatin control--A place for E2F and Myc to meet. Science 296, 1034-1035 (2002). [Abstract] [Full Text]