Actions and Consequences

Science's STKE  04 Jun 2002:
Vol. 2002, Issue 135, pp. tw202-TW202
DOI: 10.1126/stke.2002.135.tw202

Our predictive understanding of the outside world is predominantly based on learning about the relationship between stimuli (classical or "Pavlovian" conditioning) and on learning about the consequences of our own behavior (operant conditioning). The neuronal mechanisms underlying operant conditioning are largely unknown. Brembs et al. (see the Perspective by Rankin) developed an operant conditioning paradigm in the marine invertebrate Aplysia and used in vivo and in vitro experiments to unravel the cellular basis of operant conditioning of feeding behavior.

B. Brembs, F. D. Lorenzetti, F. D. Reyes, D. A. Baxter, J. H. Byrne, Operant reward learning in Aplysia: Neuronal correlates and mechanisms. Science 296, 1706-1709 (2002). [Abstract] [Full Text]

C. H. Rankin, A bite to remember. Science 296, 1624-1625 (2002). [Summary] [Full Text]