Reassessing Hippocampal Mossy Fiber LTP

Science's STKE  11 Jun 2002:
Vol. 2002, Issue 136, pp. tw208-TW208
DOI: 10.1126/stke.2002.136.tw208

It has become generally agreed that the expression of long-term potentiation (LTP) at mossy fiber-CA3 synapses in the hippocampus is a presynaptic phenomenon. The LTP induction site, however, is still controversial. Contractor et al. used intracellular infusion of peptides and antibodies, as well as extracellular ligand application, to demonstrate a role of postsynaptic interaction of GRIP protein with ephrin B receptors in the induction of LTP. Their data suggest that a retrograde signaling pathway, an ephrin B receptor-B ephrin ligand interaction, links postsynaptic induction with presynaptic expression of long-term changes in neurotransmitter release probability.

A. Contractor, C. Rogers, C. Maron, M. Henkemeyer, G. T. Swanson, S. F. Heinemann, Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP. Science 296, 1864-1869 (2002). [Abstract] [Full Text]