Editors' ChoiceG Protein-Coupled Receptors

Signaling in Sepsis

Science's STKE  11 Jun 2002:
Vol. 2002, Issue 136, pp. tw209-TW209
DOI: 10.1126/stke.2002.136.tw209

Normally, the activated protein C has a protective role in sepsis, but the mechanism has not been known. Riewald et al. find that the thrombin receptor (protease activated receptor, or PAR1) is the target for activated protein C signaling. This mechanism provides insights into the signaling pathway of immune modulatory chemokines that control the host defense system in sepsis.

M. Riewald, R. J. Petrovan, A. Donner, B. M. Mueller, W. Ruf, Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296, 1880-1882 (2002). [Abstract] [Full Text]