Sharing the Nogo Receptor

Science's STKE  02 Jul 2002:
Vol. 2002, Issue 139, pp. tw233-TW233
DOI: 10.1126/stke.2002.139.tw233

Myelin inhibits neurite outgrowth, representing a significant barrier to axon regeneration in adults. Wang et al. isolated a myelin protein that caused growth cone collapse and inhibited neurite outgrowth from myelin treated with phosphoinositol-phospholipase C. The protein was the glycophosphatidylinositol-anchored extracellular protein oligodendrocyte-myelin glycoprotein (OMgp). A receptor for OMgp was identified by expression cloning and found to be the same as the receptor for another myelin protein that also inhibits neurite outgrowth, Nogo-A. The two ligands compete for binding to the receptor NgR and bind to overlapping regions of NgR based on binding assays performed with deletion constructs. Because OMgp is extracellular, whereas Nogo-A is an intracellular protein, the authors propose that OMgp may be the physiological ligand for NgR.

K. C. Wang, V. Koprivica, J. A. Kim, R. Sivasankaran, R. Guo, R. L. Neve, Z. He, Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth. Nature 417, 941-944 (2002). [Online Journal]