Cytoskeletal Proteins and Gene Regulation: Form, Function, and Signal Transduction in the Nucleus

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Science's STKE  02 Jul 2002:
Vol. 2002, Issue 139, pp. pe30
DOI: 10.1126/stke.2002.139.pe30

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The cytoskeleton is important for controlling cell shape and cell motility and for organizing signaling complexes. Additionally, connections are being found between cytoskeletal proteins and the regulation of gene expression in the nucleus. De Lanerolle and Cole discuss new insights from plants that show that a plant member of the COOH-terminal binding protein (CtBP) and the brefeldin A adenosine diphosphate (ADP)-ribosylated subtrates (BARS) proteins, ANGUSTIFOLIA, may be a regulator of both the microtubule-based cytoskeleton and a transcriptional regulator. Additionally, they describe how actin and myosins may play similar roles in regulating gene expression in the nucleus of mammalian cells.

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