Editors' ChoiceCancer Biology

NFAT Mediates Invasion

Science's STKE  09 Jul 2002:
Vol. 2002, Issue 140, pp. tw241-TW241
DOI: 10.1126/stke.2002.140.tw241

Carcinoma cells can invade surrounding normal tissue, and integrins have been linked to promoting such progression because of their role in regulating cell adhesion and migration. Jauliac et al. report a correlation in breast and colon cancer cells between the expression of integrins containing the β4 subunit and the expression and activity of a transcription factor called NFAT. Inhibition of NFAT activity inhibited cancer cell migration in an invasion assay. NFAT activity and cell migration were also stimulated upon integrin clustering and exposure of cells to chemoattractants. Moreover, tissue from breast cancer patients revealed increased expression of both β4 and NFAT. NFATs appear to be targets of integrin activation and may be important drug targets to control cancer progression.

S. Jauliac, C. Lopez-Rodriguez, L. M. Shaw, L. F. Brown, A. Rao, A. Toker, The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nature Cell Biol. 4, 540-544 (2002). [Online Journal]