Editors' ChoiceG Protein-Coupled Receptors

Sorting Out Receptors

Science's STKE  30 Jul 2002:
Vol. 2002, Issue 143, pp. tw281-TW281
DOI: 10.1126/stke.2002.143.tw281

What are the mechanisms by which different G protein-coupled receptors (GPCRs) are recycled to the cell surface or targeted to the lysosomes for degradation? Whistler et al. (see the Perspective by Gray and Roth) describe the role that one protein, GASP (GPCR-associated sorting protein), plays in the fate of two structurally related opioid GPCRs. The COOH-terminal cytoplasmic domain of the delta opioid receptor but not that of the mu opioid receptor binds to GASP, and this interaction promotes transport to the lysosome. Several other endocytic receptors also interact with GASP, which appears to be a key player in regulating sorting to lysosomes versus recycling after endocytosis.

J. L. Whistler, J. Enquist, A. Marley, J. Fong, F. Gladher, P. Tsuruda, S. R. Murray, M. von Zastrow, Modulation of postendocytic sorting of G protein-coupled receptors, Science 297, 615-620 (2002). [Abstract] [Full Text]

J. A. Gray, B. L. Roth, A last GASP for GPCRs? Science 297, 529-531 (2002). [Summary] [Full Text]