Developmental Biology

Different Ascents on Neural Crest Cells

Science's STKE  06 Aug 2002:
Vol. 2002, Issue 144, pp. tw289-TW289
DOI: 10.1126/stke.2002.144.tw289

Neural crest cells arise in vertebrates at the junction between the developing neural tube and the surrounding ectoderm. These cells have particularly divergent fates, as they contribute to peripheral nerves, pigment cells, and cartilage in the head and neck. García -Castro et al. (see the Perspective by Trainor and Krumlauf) found that Wnt signaling is critical for inducing development of neural crest cells in the chick. Bone morphogenetic protein (BMP) signaling, however, seems not to be adequate to induce chick neural crest cells. Chick and other amniote vertebrates may well use different signaling mechanisms for initiating and maintaining neural crest cells than those used by nonamniotes, such as the frog and zebrafish.

M. I. García-Castro, C. Marcelle, M. Bronner-Fraser, Ectodermal Wnt function as a neural crest inducer, Science 297, 848-851 (2002). [Abstract] [Full Text]

P. Trainor, R. Krumlauf, Riding the crest of the Wnt signaling wave, Science 297, 781-783 (2002). [Summary] [Full Text]