Perspective

CD28 Costimulation: A Source of Vav-1 for TCR Signaling with the Help of SLP-76?

Science's STKE  06 Aug 2002:
Vol. 2002, Issue 144, pp. pe35
DOI: 10.1126/stke.2002.144.pe35

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Abstract

T cells require dual stimulation to become activated. When T cells encounter antigen-presenting cells, both the T cell receptor (TCR) and the CD28 coreceptor are ligated and activated. Michel and Acuto discuss how the adaptor SLP-76, which is recruited to the activated TCR complex, and the Rho family guanosine triphosphatase exchanger Vav-1, which is recruited by the CD28 receptor and TCR, may form a macromolecular complex that results in T cells activation. Vav-1 may serve as a central integrator between CD28 signaling and TCR signaling through its indirect effects on phosphoinositide 3-kinase-dependent signaling.

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