The Two Hats of SOS

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Science's STKE  13 Aug 2002:
Vol. 2002, Issue 145, pp. pe36
DOI: 10.1126/stke.2002.145.pe36

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Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. SOS also appears to serve as a guanine nucleotide exchanger for Rac and, thus, may be involved in cytoskeleton reorganization. Nimnual and Bar-Sagi discuss how these two activities of SOS can be regulated and how SOS may be recruited to different cellular locations through interactions with the adaptor proteins Grb2 and E3b1.

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