Editors' ChoiceCell Cycle

Controlling Population Expansion

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Science's STKE  20 Aug 2002:
Vol. 2002, Issue 146, pp. tw308
DOI: 10.1126/stke.2002.146.tw308

Several genes that function in eye development display a surprising level of conservation in gene function between mammals and invertebrates. One of these genes, mammalian Six6, is expressed early in development of the retina and also in the pituitary gland. Li et al. investigated whether this factor is involved in cell-type determination or cell proliferation of precursor cells. In Six6-/- mice, all neuronal cell types in the retina and all pituitary cell types were found, but the cell types were decreased in number, and defects were observed in both organs. Six6 associates with the corepressor Dach to block cyclin-dependent inhibitors and to allow for early progenitor cell proliferation. Hence, a tissue-specific repressor and corepressor regulate the cell cycle in an organ-specific manner.

X. Li, V. Perissi, F. Liu, D. W. Rose, M. G. Rosenfeld, Tissue-specific regulation of retinal and pituitary precursor cell proliferation, Science 297, 1180-1183 (2002). [Abstract] [Full Text]