Editors' ChoiceCell Biology

Persistent Pores in Insulin Secretion

Science's STKE  27 Aug 2002:
Vol. 2002, Issue 147, pp. tw318-TW318
DOI: 10.1126/stke.2002.147.tw318

During stimulated secretion, a secretory granule fuses with the plasma membrane to release secretory granule contents. Takahashi et al. have used two-photon excitation imaging to reveal the dynamics of the fusion pore during insulin secretion from pancreatic islets. The lifetime of the pore, which was made up mostly of membrane lipids, was much longer than anticipated from other studies with single cells.

N. Takahashi, T. Kishimoto, T. Nemoto, T. Kadowaki, H. Kasai, Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet, Science 297, 1349-1352 (2002). [Abstract] [Full Text]