Editors' ChoiceCytoskeleton

Transcriptional Regulation via ACTive Transport

Science's STKE  07 Jan 2003:
Vol. 2003, Issue 164, pp. tw12-TW12
DOI: 10.1126/stke.2003.164.tw12

Molecules called kinesins are critical for the movement of chromosomes, organelles, and messenger RNAs molecules within cells. Macho et al. now show that the testis-specific kinesin KIF17b can function in the transport of the coactivator ACT and affect transcriptional activity. ACT is a coactivator of CREM-mediated transcription in mammalian spermatids. KIF17b acts as a dose-dependent inhibitor of ACT-dependent transcription by excluding ACT from the nucleus. This work begins to address the molecular mechanism by which germ-cell gene expression is regulated.

B. Macho, S. Brancorsini, G. M. Fimia, M. Setou, N. Hirokawa, P. Sassone-Corsi, CREM-dependent transcription in male germ cells controlled by a kinesin. Science 298, 2388-2390 (2002). [Abstract] [Full Text]