Editors' ChoiceLONGEVITY

Live Lean, Live Long

Science's STKE  28 Jan 2003:
Vol. 2003, Issue 167, pp. tw46-TW46
DOI: 10.1126/stke.2003.167.tw46

Restricting food generally increases the life-span of mammals, and this effect may be related to the decrease in caloric intake or to the accompanying reduction in fat mass. Studying genetically modified mice that eat normally but cannot properly store energy in fat, Blüher et al. show that leanness alone is associated with a modest (18%) increase in mean life-span, possibly through effects on insulin signaling.

M. Blüher, B. B. Kahn, C. R. Kahn, Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572-574 (2003). [Abstract] [Full Text]