Book Review

Book Review: A Widely Conserved Smell of Danger

Science's STKE  25 Feb 2003:
Vol. 2003, Issue 171, pp. pe9
DOI: 10.1126/stke.2003.171.pe9

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Review and commentary on Toll-like Receptor Family Members and Their Ligands, edited by Bruce Beutler and Hermann Wagner. Springer-Verlag, Berlin, Heidelberg, 2002, 192 pp. $95.00, ISBN: 3-540-43560-3


With more than 150 original articles and more than a dozen reviews having been published in 2002 on the Toll-like receptor (TLR) family, the book Toll-like Receptor Family Members and Their Ligands provides a timely overview of the role of TLRs in innate immunity. The book provides chapters on the receptors, their ligands, and the signaling cascades activated. Highlighted in this book review are the chapters on the evolution of the TLRs, the receptor-ligand specificity, and the possible cross-talk between TLR signaling pathways and mitogen-activated protein kinase pathways.

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