Plant biology

Degrading the Opposition

Science's STKE  25 Mar 2003:
Vol. 2003, Issue 175, pp. tw122-TW122
DOI: 10.1126/stke.2003.175.tw122

Growth and development in plants is carefully regulated in response to both intrinsic and extrinsic signals, in part by the hormone gibberellic acid. Sasaki et al. (see the Perspective by Harberd) have now elucidated some of the forces that set up opposing positive and negative controls on gibberillin signaling. A newly identified protein from rice, GID2, functions as a positive regulator by pitching the opposing negative regulator, SLR1, into the hands of the proteosome, where it is promptly degraded.

A. Sasaki, H. Itoh, K. Gomi, M. Ueguchi-Tanaka, K. Ishiyama, M. Kobayashi, D.-H. Jeong, G. An, H. Kitano, M. Ashikari, M. Matsuoka, Accumulation of phosphorylated repressor for gibberellin signaling in an f-box mutant. Science 299, 1896-1898 (2003). [Abstract] [Full Text]

N. P. Harberd, Relieving DELLA restraint. Science 299, 1853-1854 (2003). [Summary] [Full Text]