Editors' ChoiceDevelopmental Biology

Forced to Close

Science's STKE  08 Apr 2003:
Vol. 2003, Issue 177, pp. tw140-TW140
DOI: 10.1126/stke.2003.177.tw140

Dorsal closure occurs in the Drosophila embryo and resembles movements in vertebrate development and wound healing. Hutson et al. (see the Perspective by Martin and Parkhurst) describe the relative contributions of various tissues and components required to drive the key morphogenetic process of dorsal closure. They used laser microsurgery and mathematical modeling methods to determine the force contributions from four different cell movements: amnioserosal contraction, supracellular purse-string contraction, lateral epidermal stretching, and filopodial zippering. The robustness of this process comes from a balance of the various forces involved. The quantitative model was then applied to a dorsal closure mutant to identify how the different force components were affected.

M. S. Hutson, Y. Tokutake, M.-S. Chang, J. W. Bloor, S. Venakides, D. P. Kiehart, G. S. Edwards, Forces for morphogenesis investigated with laser microsurgery and quantitative modeling. Science 300, 145-149 (2003). [Abstract] [Full Text]

P. Martin, S. M. Parkhurst, May the force be with you. Science 300, 63-65 (2003). [Summary] [Full Text]