Protecting the Vascular Wall

Science's STKE  15 Apr 2003:
Vol. 2003, Issue 178, pp. tw151
DOI: 10.1126/stke.2003.178.tw151

Atherosclerosis is characterized by aberrant growth and migration of vascular smooth muscle cells. In a study of genetically engineered mice, Boucher et al. identify LRP1 (low density lipoprotein receptor-related protein 1) as an important physiological regulator that helps to keep these cells in check. The atheroprotective effect of LRP1 was traced to its ability to control signaling events involving the platelet-derived growth factor receptor.

P. Boucher, M. Gotthardt, W.-P. Li, R. G. W. Anderson, J. Herz, LRP: Role in vascular wall integrity and protection from atherosclerosis. Science 300, 329-332 (2003). [Abstract] [Full Text]