Review

The Structure and Function of Proline Recognition Domains

Science's STKE  22 Apr 2003:
Vol. 2003, Issue 179, pp. re8
DOI: 10.1126/stke.2003.179.re8

You are currently viewing the gloss.

View Full Text

Via your Institution

Log in through your institution

Log in through your institution


Gloss

This STKE Review describes one class of protein interaction domains: the proline-binding domains. Conserved protein domains are critical to the assembly and regulation of many intracellular signaling complexes and pathways. Proline-binding domains serve two main functions: to serve as assembly points in signaling complexes and to serve a regulatory role in controlling protein activity. With seven figures and one table, this review provides detailed structural information about three main proline-binding motifs (the SH3, WW, and EVH1 domains), as well as brief descriptions of other proline-binding domains. The review has 91 references, seven figures, one table, and five interactive images.

Related Content