Synaptic Plasticity

Creating Left-Right Asymmetry in the Hippocampus

Science's STKE  13 May 2003:
Vol. 2003, Issue 182, pp. tw186-TW186
DOI: 10.1126/stke.2003.182.tw186

The NR2B subunit of the NMDA receptor is a major prerequisite for learning and memory. A dynamic rearrangement of this subunit occurs during development and after synaptic modifications. Kawakami et al. show that, in the adult mouse hippocampus, the NR2B subunit is asymmetrically distributed in glutamatergic synapses deriving from ipsilateral versus contralateral afferents. There is also an asymmetric NR2B distribution between synapses on the basal and apical dendrites of pyramidal neurons.

R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry. Science 300, 990-994 (2003). [Abstract] [Full Text]