Double-Teaming the Aging Process

Science's STKE  20 May 2003:
Vol. 2003, Issue 183, pp. tw199-TW199
DOI: 10.1126/stke.2003.183.tw199

Two transcription factors that control longevity in the nematode Caenorhabditis elegans code are HSF-1, which is induced by heat stress, and DAF-16, a member of FOXO family. Hsu et al. show that these transcription factors act together to regulate a set of genes, including those for small heat shock proteins (HSPs), which themselves regulate life-span. These small HSPs may counteract aging effects by binding to damaged proteins and preventing the formation of harmful aggregates.

A.-L. Hsu, C. T. Murphy, C. Kenyon, Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 1142-1145 (2003). [Abstract] [Full Text]