Infectious Synapse

Science's STKE  27 May 2003:
Vol. 2003, Issue 184, pp. tw205
DOI: 10.1126/stke.2003.184.tw205

Dendritic cells (DCs) may play a role in host-pathogen interactions. For example, certain proteins expressed on DCs, such as DC-SIGN, can stimulate the efficiency of infection of target cells by the human immunodeficiency virus (HIV). McDonald et al. visualized individual particles of HIV in living cells and found that DC-associated HIV was recruited to the site of contact with target cells such as T cells. Simultaneously, the HIV receptor and coreceptor were recruited to the contact site. This recruitment effectively concentrates HIV, its receptor, and its coreceptor and presumably facilitates infection.

D. McDonald, L. Wu, S. M. Bohks, V. N. KewalRamani, D. Unutmaz, T. J. Hope, Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science 300, 1295-1297 (2003). [Abstract] [Full Text]